Transforming Growth Factor Beta 1 869T/C and 915G/C Polymorphisms and Risk of Autism Spectrum Disorders

نویسندگان

  • Abdolreza Varasteh Allergy Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
  • Farhad Salari Immunology Research Center, Medical School, Mashhad University of Medical Sciences, Mashhad, Iran
  • Maryam Hojati Noor Hedayat Center of Autism Spectrum Disorders, Mashhad, Iran
  • Maryam Javanbakht Department of Psychiatrics, Islamic Azad University, Mashhad Branch, Mashhad, Iran
  • Mohammad Reza Khakzad Allergy Research Center, Mashhad University of Medical Sciences, Mashhad, Iran - Department of Immunology, Mashhad Branch, Islamic Azad University, Mashhad, Iran
  • Mojtaba Meshkat Department of Biostatistc, Shahid Beheshti University of medical sciences, Tehran, Iran
  • Mojtaba Sankian Immunology Research Center, Medical School, Mashhad University of Medical Sciences, Mashhad, Iran
چکیده مقاله:

Background: Transforming growth factor-β1 (TGF-β1) has been found to play a crucial role in early central nervous system development. Several studies have illustrated decreased TGF-β1 levels in sera and brains of autistic children. Two point mutations in the TGF-β1 signal peptide at 869T/C and 915G/C have been reported to influence TGF-β1 expression. The aim of the present study was to investigate the correlation of TGF-β1 polymorphisms and their haplotypes with autism. Methods: This study was performed on 39 autistic patients and 35 age- and sex-matched normal controls in an Iranian population, using the sequence specific primed-polymerase chain reaction (PCR-SSP) technique. Patients were divided into mild-to-moderate and severe groups according to the childhood autism rating scale. Results: No significant differences were observed for allele, genotype, or haplotype frequencies between the autistics and controls. Only a slight difference was observed in GC25 between the controls and all children with autism. Conclusion: Thus, these results indicate that the polymorphisms in TGF-β1 gene may not play an important role in the development of autism.

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transforming growth factor beta 1 869t/c and 915g/c polymorphisms and risk of autism spectrum disorders

background: transforming growth factor-β1 (tgf-β1) has been found to play a crucial role in early central nervous system development. several studies have illustrated decreased tgf-β1 levels in sera and brains of autistic children. two point mutations in the tgf-β1 signal peptide at 869t/c and 915g/c have been reported to influence tgf-β1 expression. the aim of the present study was to investig...

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Transforming growth factor beta 1 869T/C and 915G/C polymorphisms and risk of autism spectrum disorders.

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عنوان ژورنال

دوره 3  شماره 2

صفحات  82- 88

تاریخ انتشار 2015-05

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